Biology stands on the brink of a shift in the understanding of inheritance. The discovery of epigenetics-hidden influences upon the genes could affect every aspect of our lives.
At the heart of this new field is a simple but contentious idea that genes have a ‘memory’. It’s that the lives of your grandparents, the air they breathed, the food they ate, even the things they saw, can directly affect you, decades later, despite your never experiencing these things yourself. And that what you do in your lifetime could in turn affect your grandchildren.
The conventional view is that DNA carries all our heritable information, and that nothing an individual does in their lifetime will be biologically passed to their children. To many scientists, epigenetics amounts to be heresy, calling into question the accepted view of the DNA sequence, a cornerstone on which modern biology sits.
Epigenetics adds a whole new layer to genes beyond the DNA. It proposes a control system of ‘switches’ that turn genes on or off, and suggests that things people experience, like nutrition and stress, can control these switches and cause heritable effects in humans.
In a remote town in northern Sweden, there is evidence for this radical idea. Lying in Overkalix’s parish registries of births and deaths and its detailed harvest records is a secret that confounds traditional scientific thinking. Marcus Pembrey, a Professor of Clinical Genetics at the Institute of Child Health in London, in collaboration with Swedish researcher Lars Olov Bygren, has found evidence in these records of an environmental effect being passed down the generations. They have shown that a famine at critical times in the lives of the grandparents can affect the life expectancy of the grandchildren. This is the first evidence that an environmental effect can be inherited in humans.
In other independent groups around the world, the first hints that there is more to inheritance than just the genes are coming to light. The mechanism by which this extraordinary discovery can be explained is starting to be revealed.
Professor Wolf Reik at the Babraham Institute in Cambridge, has spent years studying this hidden ghost world. He has found that merely manipulating mice embryos is enough to set off ‘switches’ that turn genes on or off.
For mothers like Stephanie Mullins, who had her first child by in vitro fertilization, this has profound implications. It means it is possible that the IVF procedure caused her son Ciaran to be born with Beckwith-Wiedemann Syndrome, a rare disorder linked to abnormal gene expression. It has been shown that babies conceived by IVF have a three to four fold increased chance of developing this condition.
Reik’s work has gone further, showing that these switches themselves can be inherited. This means that a ‘memory’ of an event could be passed through generations. A simple environmental effect could switch genes on or off, and this change could be inherited. His research has demonstrated that genes and the environment are not mutually exclusive, but are inextricable intertwined, one affecting the other.
The idea that inheritance is not just about which genes you inherit, but whether these are switched on or off, is a whole new frontier in biology. It raises questions with huge implications, and means the search will be on to find what sort of environmental effects can affect these switches.
After the tragic events of September 11th, 2001, Rachel Yehuda, a psychologist at the Mount Sinai School of Medicine in New York, studied the effects of stress on a group of women who were inside or near the World Trade Center and were pregnant at the time. Produced in conjunction with Jonathan Seckl, an Edinburgh doctor, her results suggest that stress effects can pass down generations.
Meanwhile, research at Washington State University points to toxic effects like exposure to fungicides or pesticides causing biological changes in rats that persist for at least four generations.
This work is at the forefront of a paradigm shift in scientific thinking. It will change the way the causes of disease are viewed, as well as the importance of lifestyles and family relationships. What people do no longer just affects themselves, but can determine the health of their children and grandchildren in decades to come. “We are,” as Marcus Pembrey says, “all guardians of our genome.”
Geneticists were especially surprised to find that epigenetic change could be passed down from parent to child, one generation after the next. A study from Randy Jirtle of Duke University showed that when female mice are fed a diet rich in methyl groups, the fur pigment of subsequent offspring is permanently altered. Without any change to DNA at all, methyl groups could be added or subtracted, and the changes were inherited much like a mutation in a gene.